Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
نویسندگان
چکیده
منابع مشابه
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according...
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ژورنال
عنوان ژورنال: Science
سال: 2010
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1183090